Argentina can clinch top spot in Group B with a point in their final group match against Greece in Polokwane.
Greece, the 2004 European champions, need nothing short of a miracle to secure their progression to the second round.
Otto Rehhagel's side need to win by a whopping three-goal margin against red-hot Argentina to advance to the knockout stage.
Should they fail to secure a win by three or more goals, they would be left waiting on the result of the Nigeria and South Korea match before learning their fate.
Argentina have looked one of the teams to beat so far in the tournament with two wins from two, including a 4-1 thumping of South Korea.
Maradona has plans to rest his key personnel, although Barcelona star Lionel Messi is set to retain his place up front.
While captain Javier Mascherano and strikers Carlos Tevez and Gonzalo Higuain will be rested, Messi will stay in the starting line-up.
Juan Sebastian Veron, who missed the win over South Korea with a calf injury, will return in place of Liverpool ace Mascherano.
With Tevez and Higuain missing the likes of Sergio Aguero, Diego Milito or Martin Palermo will be vying to get the nod.
Wing back Jonas Gutierrez is suspended after collecting two bookings while Gabriel Heinze, who is also on a booking, could be rested.
Greece come into the match with their tails up after responding to their defeat against South Korea with a 2-1 win over Nigeria, their first finals success.
However, midfielder Thanassis Prittas has hinted the team will stick with its trademark defensive tactics against Argentina despite its slim chances of progressing without a win.
Rehhagel is not planning on making wholesale changes and in fact, Greece are expected to name the same starting XI that came from behind to beat The Super Eagles last Thursday.