European champions Spain must get a result against Honduras to keep their World Cup hopes alive.
Switzerland produced the shock of the tournament so far when they beat Vicente del Bosque's men 1-0 in their opening game, a result which leaves Spain in a poor position in Group H.
With Chile beating Honduras in their first match, the race to qualify for the knockout stage is now wide open.
Indeed, if Switzerland and Chile play out a draw and Honduras manage a surprise win, Spain will be out of the tournament.
It would be a remarkable turn of events considering La Roja were tipped to go all the way before the competition kicked off, but a defeat against Honduras is surely unthinkable.
Spain will be clear favourites to take all three points at Ellis Park on Monday, but Honduras come into the game without any of the pressure that will be hanging over their opponents.
Liverpool striker Fernando Torres is pushing for a start after featuring as a substitute in the first game.
Spain had all the possession against the Swiss but despite their domination, could not find a way past a stubborn defence.
David Villa was kept at bay, but he may be partnered by Torres as Del Bosque looks for a more attacking line-up.
Sergio Ramos is expected to shake-off a rib injury.
Cesc Fabregas has revealed he is desperate to play but Spain may go with a midfield of Iniesta, Xavi, Xabi Alonso and David Silva, while Sergio Busquets could drop out if Torres starts.
Honduras striker David Suazo could return to the side after a thigh injury which ruled him out of the Chile tie.
If the Inter Milan man recovers in time, he could replace Edgar Alvarez.